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diagnosis hematology differential management clinical algorithm microscopy anemia abcs blood causes nephrology smear pathophysiology urine rbc pathology treatment workup hemolytic
Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Red Blood Cell (RBC ... spur cell), Basophilic ... cell, Other RBC ... Howell-Jolly bodies #RBC
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Common RBC Inclusions ... Hemoglobin H disease • Basophilic ... Sickle cell, MDS #RBC
Nucleated red blood cells, aka normoblasts or erythroblasts, were released prematurely from the bone marrow in
proerythroblast – basophilic ... Smear #Nucleated #RBCs
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
- Fe/TlBC, MCV/RBC ... TIBC Normal - MCV/RBC ... <13, +/- basophilic ... inclusions in RBC
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
thalassemia, S Lepore • Basophilic ... hypertension • Unusual RBC ... acanthocytes - Consider RBC
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Diagnosis Framework Basophils ... blood cell count Basophils ... Is It A Real Basophilia ... myeloid leukemia - Basophils
Morphologic Findings in Red Blood Cells Basophilic stippling - Small blue dots in red cells, due to
Red Blood Cells Basophilic ... and grayer than basophilic ... RedBloodCells #RBCs
Urine Microscopy and Casts - Image Atlas Key - Squamous Epithelial Casts - Transitional Epithelial Cells - Renal Tubular
Hyaline Cast - WBCs ... - Monomorphic RBCs ... - Dysmorphic RBCs ... - WBC Cast - RBC
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Normal/lncreased WBCs ... Macrocytes, Normal RBCs ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... ) - Abnormal RBCs
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Urinalysis >3 RBCs ... of UTI, urine WBCs ... (proteinuria, RBC ... casts, dysmorphic RBCs
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