13 results
Bilirubin Crystals on Urine Microscopy

Dr. Telma Lemos @TELMALEMOS10

#Bilirubin #Crystals #crystalluria #Urine #Microscopy #trichomoniasis #clinical
Bilirubin Crystals ... on Urine Microscopy ... TELMALEMOS10 #Bilirubin ... #Crystals #crystalluria ... #Urine #Microscopy
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Testing in Hemolytic Anemia ... Unconjugated bilirubin ... LDH Peripheral smear ... Haptoglobin Urine ... hemosiderin Urine
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood Smear ... Megaloblastic Anemia ... , Thalassemia Basophilic ... Peripheral #Blood #Smear ... Analysis #hematology #microscopy
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... - Differential ... / unconjugated bilirubin ... Abnormal peripheral smear ... #Differential #
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Reticulocytes, smear ... Haptoglobin, LDH, Urine ... MAHA likely: • Smear ... Total/indirect bilirubin ... Haptoglobin • ↑ Urine
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential ... Normochromic RBCs on Smear ... Increased Unconjugated Bilirubin ... Spherocytes on Smear ... Classification #Approach #Differential
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... haptoglobin ↑ indirect bilirubin ... C3d • Blood smear ... : Differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... Peripheral Blood Smear ... - Unconjugated Bilirubin ... #Hemolysis #Differential
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Algorithm and Differential ... blood count with differential ... , urine microscopy ... , haptoglobin, bilirubin ... Workup #Algorithm #Differential
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... Peripheral blood smear ... immune hemolytic anemia ... Indirect bilirubin ... WBC count and differential