22 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... ALL (Acute Lymphoblastic ... extramedullary disease ... Philadelphia - BCR-ABL ... lymphoid organs When Cancer
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal

PRE-RENAL 
Impaired perfusion: 
•
Kidney Injury ( ... • Sepsis • Blood ... • Inflammatory disease ... #Kidney #Injury ... #Differential #Nephrology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... LC deposition disease ... Minimal change disease ... malignancies Treatment ... Classification #Nephrology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
blood loss, Acute ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD, Celiac disease
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... cells can indicate disease ... Lymphocytosis: Absolute blood ... microglobulin Treatment ... ’s lymphoma or acute
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... associated with the BCR-ABL1 ... translocation • Acute ... thrombocythemia • Acute ... Colitis and Crohn’s Disease
Hematuria in Post-Renal Transplant Patient
Prevalence up to 12% in the postrenal transplant patient
 • Bacterial: Escherichia
carcinoma., Prostate cancer ... , Busulfan • Disease ... diagnosis #kidney #blood ... urine #management #treatment ... #nephrology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Chronic kidney disease ... infiltration (e.g. cancer ... Index > 3: • Acute ... defects (e.g. sickle cell ... Production #Index #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
concentrations in: RBCs ... disease, deficiency ... of red blood cell ... : • Early acute ... hepatitis • Acute
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... B-LNH), solid cancers ... • Autoimmune diseases ... Unknown cause Treatment ... #summary #rheumatology