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Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... Congestion • Medications ... Immune-complex disease ... Bilateral ureteral disease ... #Kidney #Injury
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Circulation Failure Kidney ... Drug-Induced Liver Injury
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... • Glomerular disease ... tract infection • Medications ... #Kidney #Injury ... Classification #diagnosis #nephrology
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
Kidney Injury ... • Drug induced acute ... kidney injury is ... • Treatment includes ... Vancomycin #AKI #pharmacology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... LC deposition disease ... Minimal change disease ... malignancies Treatment ... #Kidney #Injury
Acute Kidney Injury (AKI) - Management Principles
Prerenal - Correct hemodynamic derangements:
 • If low preload →
Acute Kidney Injury ... underlying liver disease ... the underlying disease ... → No specific treatment ... #Kidney #Injury
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... duration), Several medications ... non-essential drug/HDS treatments ... Alcohol-related liver disease ... dechallenge • Acute
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Torsemide) • Acute ... hyperaldosteronism • Acute ... Tolvaptan) • Treatment ... #Pharmacology # ... Medications #Table
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
An acute rise or ... heart failure, neurologic ... kidney injury). ... Renal parenchymal disease ... Neurologic disorders