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diagnosis differential nephrology hepatology aki management liver algorithm causes classification aclf aih alcoholic autoimmune cancer chemistry chronic cirrhosis dehydrogenase dili
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Kidney Failure ... Drug-Induced Liver Injury
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... Dehydration • Heart failure ... syndrome) • Liver failure ... #Kidney #Injury ... Classification #diagnosis #nephrology
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal PRE-RENAL Impaired perfusion: •
Kidney Injury ( ... perfusion: • Cardiac failure ... • Inflammatory disease ... #Kidney #Injury ... #Differential #Nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... HEMODYNAMIC • Cardiac failure ... • Primary GNs: Disease ... Due to systemic disease ... Tubular Injury/
Vancomycin Associated Acute Kidney Injury • Drug induced acute kidney injury is generally defined as a
Kidney Injury ... • Drug induced acute ... kidney injury is ... • Treatment includes ... Vancomycin #AKI #pharmacology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Acute Kidney Injury ... LC deposition disease ... Minimal change disease ... malignancies Treatment ... #Kidney #Injury
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... Liver Failure ( ... of cholestatic disease ... Alcoholic liver disease
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Torsemide) • Acute ... hyperaldosteronism • Acute ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology ... #Pharmacology #
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... non-essential drug/HDS treatments ... Alcohol-related liver disease ... dechallenge • Acute ... • Autoimmune hepatitis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
concentrations in: RBCs ... muscle, liver, and kidney ... : • Early acute ... hepatitis • Acute ... Hepatocellular Injury
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