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diagnosis management oncology differential algorithm causes cll lymphocytic nephrology workup aclf anemia basophilia basophils behcet calcium calculation cirrhosis ckd cppd
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Myelogenous Leukemia ... Infectious: • Acute ... disorders • Celiac disease ... effect following treatment ... Algorithm #Causes #Hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Kidney Failure ... #Chronic #Liver
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Disorders: • Chronic ... associated with the BCR-ABL1 ... translocation • Acute ... Colitis and Crohn’s Disease ... Diagnosis #causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... Chronic leukemia ... extramedullary disease ... Philadelphia - BCR-ABL ... #Hematology #Oncology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
kidney disease, ... kidney disease, ... kidney disease ... kidney disease ... Tolvaptan) • Treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... microglobulin Treatment ... • Bone marrow failure ... ’s lymphoma or acute ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... chemotherapy for low-risk disease ... Progressive bore marrow failure ... uw_IMresidency #CLL #Chronic ... #oncology #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
• Anemia of chronic ... kidney disease, ... • Bone marrow failure ... Index > 3: • Acute ... Production #Index #hematology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... lesions, meninges, kidneys ... hypergammaglobulinemia, ↑ acute ... maintenance with GCs ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... C4) • ds-DNA: Kidney ... with Lupus: • Chronic ... Hodgkin lymphoma and leukemia ... Erythematosus #Diagnosis #Rheumatology
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