10 results
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
NEJM 1999 - ICU FOCUS ... blood is a liquid ... Blood saves lives ... unnecessary and cause ... #Thresholds #Hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... - Allergic ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... • Allergic reaction ... Causes purpura & ... TRALI): Leading cause ... diagnosis #management #hematology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... lgE causes mast-cell ... lgM antibodies bind ... Examples: Acute transfusion ... #types #allergy
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... Reactions TRALI ... of high parity blood ... without other cause ... #Reactions #hematology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lgE antibodies bind ... - Red blood cell ... destruction after transfusion ... with mismatched blood ... #Diagnosis #Reactions
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... released during an allergic ... reaction or asthma ... Or Inflammatory Reactions ... #hematology #basophils
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... for secondary causes ... eosinophilia (common causes ... are asthma, allergy ... , drug reaction,
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
maintained fever CAUSES ... urological device • Blood ... transfusion • ... Allergic reaction ... • Intracranial blood
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Causes: - Idiopathic ... CANDLE syndrome - Allergic ... neutrophils in the blood ... Syndrome #diagnosis #dermatology ... #oncology