18 results
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
Immune Reactions ... #Pharmacology #Pathophysiology ... #immunology
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
Antibodies that bind ... to an allergic reaction ... Allergen-antibody complexes bind ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Symptoms Distinguishing Groups of Cutaneous Drug Reactions
IgE-mediated reactions:
 • Onset minutes to hours into treatment course
Cutaneous Drug Reactions ... IgE-mediated reactions ... T-cell-mediated reactions ... #dermatology #clinical ... #comparison #classification
Type II Hypersensitivity: Pathogenesis and clinical findings
Definition: When antigens bind to the body's cell surfaces, forming
When antigens bind ... antibody-mediated immune reaction ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
hypersensitivity reaction ... #Anaphylaxis #pathophysiology ... #immunology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... lgM antibodies bind ... Acute transfusion reaction ... hypersensitivity #reactions ... allergy #table #classification
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... pericarditis • Hematologic ... lupus nephritis Immunologic ... #EULARACR #Classification ... Erythematosus #diagnosis #rheumatology
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Allergic reaction ... HypersensitivityReaction #Allergy #Immunology ... #pathophysiology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
• Transfusion reactions ... Diagnosis #causes #classification ... #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
- Transfusion Reactions ... blood donor • Pathophysiology ... transfusion • Pathophysiology ... #Transfusion #Reactions ... #hematology #diagnosis