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diagnosis management blood differential product anemia biliary cholangitis cirrhosis classification coagulation dic disseminated hemolysis hemolytic intravascular pbc primary table taco
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Reactions TRALI ... without other cause ... • Pathophysiology ... #Reactions #hematology ... #diagnosis #comparison
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
AIHA, Cold AIHA, Transfusion ... reactions, Drug-associated ... Defects, Drugs, Liver ... - Unconjugated Bilirubin ... Differential #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Anemia Intrinsic Causes ... : • Liver disease ... prosthetic valve • Transfusion ... reactions ex. ... classification #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... eruptions, diarrhea, liver ... more likely to cause ... diagnosis #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... eruptions, diarrhea, liver ... more likely to cause ... diagnosis #management #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... slightly elevated • Bilirubin ... or higher • Liver ... diagnosis #workup #hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
incompatible blood transfusion ... protein C and S Pathophysiology ... DIC • Severe Liver ... Treat primary cause ... treatment #management #hematology
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