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differential hematology management sle erythematosus hemolytic symptoms systemic warm antibody bullous cold druginduced hemeonc hemophagocytic hlh inflammatory lymphohistiocytosis mimickers monoclonal
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... LDH • Anti-RBC autoantibodies ... #diagnosis #management ... #treatment #rheumatology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Hemolytic Anemia ... Spherocytes • Treatment ... transient hemolysis • Treatment ... #hematology #diagnosis ... #comparison
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... #differential #diagnosis ... #comparison #rheumatology ... #table
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... - Hemolytic anemia ... #autoantibodies ... #signs #symptoms ... #differential #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
months) and of autoantibodies ... life-threatening • Treatment ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
Pemphigus Vulgaris vs Bullous Pemphigoid - Comparison Table Pemphigus Vulgaris • Epidemiology: Average age 40-60 • Time
Bullous Pemphigoid - Comparison ... Table Pemphigus ... ruptured • Nikolsky sign ... • Antibodies: Autoantibodies ... #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... rheumatologic diseases ... lymphopenia, low PLT • Anemia ... #Rheumatology
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
associated with rheumatologic ... presentation of systemic lupus ... Pericarditis #Symptoms #Signs ... #Presentation #comparison ... #Table #Diagnosis
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 Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
syndrome • CVST • Bing-Neel ... macular Vasculitis) Autoantibodies ... (-) hemolytic anemia ... to cold IgG • Lupus ... #Differential #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Malignancies ▪ Autoimmune ... Presentation • Common Signs ... - Cytopenias (anemia ... Infections, malignancy, autoimmune ... #Management #Hematology
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