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differential dermatology management sle symptoms algorithm erythematosus oncology systemic hairloss vasculitis workup anemia arthritis classification dermatomyositis diffuse focal joint leukemia
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Diagnosis Framework ... Capitis - Skin ... Disease: Discoid lupus ... , Loose anagen syndrome ... Examination: • Signs
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
) Differential Diagnosis ... • Loose anagen syndrome ... - Secondary to Skin ... • Discoid lupus ... #causes
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... /Symptoms Alopecia ... Erythematosus #SLE #Signs ... #Symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Photosensitivity, Alopecia ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Skin Conditions ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... #differential #diagnosis ... #rheumatology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
areas -> Scaring alopecia ... hair follicles -> causes ... inflammation on skin ... pathophysiology #diagnosis ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Associated with skin ... #Systemic #Lupus ... #SLE #Summary #diagnosis ... #rheumatology #
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... antiphospholipid syndrome ... S - Systemic Lupus ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... and permanent alopecia ... Differential Diagnosis ... • Nonscarring alopecia ... #Rheumatology
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