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hematology differential treatment workup diarrhea hemophagocytic infectiousdiseases lymphohistiocytosis criticalcare infection reactions rheumatology 1 acute aids antibiotics cdi cdiff challenges chronic
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... Phagocytosis of blood ... Auto-amplification loop Diagnosis ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... can mimic common infections ... Splenomegaly • Low ... Treatment: • Infection ... #management #treatment
Algorithm for the Evaluation of Acute Diarrhea (< 7 days) Are the following present? 1.
Algorithm for the ... HIV infection or ... Bloody diarrhea, ... #management #algorithm ... #workup #diagnosis
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
and Management ... Independent (↑ PTH) • LOW ... Intake (diet) - Activation ... Pancreatitis, Blood ... #differential #algorithm
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... SLE], AOSD) • Infection ... Fibrin degradation products ... #Syndrome #Diagnosis ... #Management #Hematology
Algorithm for the Evaluation of Chronic Diarrhea (< 7 days) Exclude: 1. Causes of acute diarrhea 2. Lactose intolerance 3.
Algorithm for the ... Parasitic infections ... leukocytes and occult blood ... #management #algorithm ... #workup #diagnosis
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... cutaneous eruptions, diarrhea ... Blood products contain ... Hypothermia: Due to low ... #diagnosis #management
Diarrhea Workup and Management Algorithm in Transplant Patients First Tier Microbiologic-Testing: 1. C. difficile PCR (Stool) 2. CMV qPCR
and Management Algorithm ... CMV qPCR (Serum/Blood ... Ova and Parasite ... #Workup #Management ... #diagnosis #differential
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
cutaneous eruptions, diarrhea ... Blood products contain ... Hypothermia: Due to low ... Infection - Infection ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... by uncontrolled activation ... Triggers: ▪ Infections ... Low/absent NK-cell ... underlying trigger: Infections
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