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diagnosis rheumatology differential dermatology lupus management erythematosus syndrome classification cutaneous signs skin symptoms acute ana antibodies antibody antineutrophil antinuclear aortitis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... in drug-induced SLE ... ) • Systemic sclerosis ... Vasculitis: • ... Renal-limited vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... livedo reticularis, ulcers ... genital aphthous ulcers ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... nodules, Deep ulcers ... • ANCA Associated ... : • Behcet Disease ... #rheumatology #
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
(Oropharyngeal Ulcers ... Pleuritis) H Hematologic ... Arthritis R Renal Disease ... #IMDAMNSHARP #sle ... #systemic #lupus
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... Nodosa (PAN), ANCA ... associated vasculitis ... Arthritis (RA), Systemic ... erythematosus (SLE
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Alopecia, oral ulcers ... Positive in 60-80% of cases ... Evolution: Chronic disease ... #lupus #Systemic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... livedo reticularis, ulcers ... tract, and often causes ... purpura, nodules or ulcers ... genital aphthous ulcers
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... Splenomegaly - CTD (SLE ... Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE ... Differential #Diagnosis #hematology
Mucous Membrane Disorder - Differential Diagnosis Algorithm Erosions/Ulcers/Blisters - Primary Dermatologic Diseases •
Differential Diagnosis Algorithm ... Erosions/Ulcers ... necrolysis - Systemic ... Systemic lupus ... #causes
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm ... #rheumatology
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