11 results
Atypical HUS - Hemolytic Uremic Syndrome
Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Uremic Syndrome ... autoimmune like SLE ... present with anemia, thrombocytopenia ... Especially if concern ... If this is aHUS,
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • ... #Causes #Hematology
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
MAHA + thrombocytopenia ... TTP (atypical HUS ... catastrophic APS, SRC, SLE ... ), cancer, transplant ... Microangiopathy #TMAs #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Vasculitides, IBD ... Kawasaki, Nephrotic syndrome
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... incompetent • CLL is ... non-Hodgkin lymphoma SLL ... Neutropenia, anemia, thrombocytopenia ... microglobulin Treatment
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
failure • Fever is ... erythematosus [SLE ... leukopenia, anemia, and thrombocytopenia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... infiltrates (anemia, thrombocytopenia ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... #Leukemia #Hematology
Acute Retroviral Syndrome
Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection

 •
Acute Retroviral Syndrome ... Nausea, vomiting, diarrhea ... Mild anemia • Thrombocytopenia ... • New onset SLE ... antibody test) Treatment
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
standing for: - Thrombocytopenia ... erythematosus (SLE ... cirrhosis - TTP/HUS ... mimics that of MCD; thus ... Hypoalbuminemia Treatment
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... often a cancer. ... Cytopenias (anemia, thrombocytopenia ... Treatment Approach ... Diagnosis #Management #Hematology