22 results
Cutaneous and Systemic Findings in Dermatomyositis
Cutaneous Findings:
 - Heliotrope sign and edema
 - Nail-fold changes
 -
- Heliotrope sign ... or shawl sign ... - Gottron's sign ... scale - Holster sign ... #Diagnosis #Rheumatology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... heliotrope rash, Shaw sign ... , holster sign, ... myositis, and arthritis ... Myositis #diagnosis #rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... anti-NXP2 Abs Lung ... #rheumatology #
Anterior ischemic optic neuropathy (AION) - Recognition of giant cell arteritis (GCA)

1) Is visual loss caused
of giant cell arteritis ... posterior ciliary arteries ... Doppler US : halo sign ... GiantCellArteritis #GCA #Rheumatology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophilia, 500-1,500 cells ... Hypereosinophilia, >1,500 cells ... allergy, drug reaction ... organ-specific signs ... Differential #diagnosis #hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
effusion, Restrictive lung ... of hip (rare), Arthritis ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Inflammatory Myopathies Dermatomyositis ... heliotrope, shawl sign ... diagnosis #comparison #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Manifestations: - Arthritis ... Myositis 4% - Lung ... autoantibodies #signs ... #differential #rheumatology
Rheumatoid Arthritis Summary
Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders
Signs & Symptoms:
Rheumatoid Arthritis ... knees, shoulders Signs ... #Rheumatoid #Arthritis ... #diagnosis #management ... #rheumatology
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... shoulders (in a shawl sign ... Non-small-cell lung ... #diagnosis #management ... #rheumatology #