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diagnosis hematology differential management anemia signs symptoms autoimmune deficiency fever oncology refeeding agglutinin ahus aiha algorithm antibody ascorbicacid atypical bacilliformis
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA Warm AIHA: - 70%; IgG mediated -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... or negative - Smear ... C3 positive - Smear ... #Anemia #Pathophysiology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... reticulocytes • Hemolysis ... C3d • Blood smear ... Antibody #Autoimmune #Hemolytic ... #management #treatment
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
• Vitamin E - Haemolytic ... anaemia, ataxia ... Wernicke-Korsakoff syndrome ... Vitamin B12 - Anaemia ... signs #symptoms #nutrition
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
diarrhoea, Short bowel syndrome ... dental fixatives, Treatment ... Total parenteral nutrition ... /jejunal nutrition ... Haematological: Anaemia
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... • Seizures • Hemolysis ... hyperparathyroidism Treatment ... #Nutrition #Differential ... #Diagnosis #Pathophysiology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... Nutritional
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Defects: Sickle cell anemia ... Peripheral Blood Smear ... Urobilinogen #Hemolysis
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
Refeeding Syndrome ... - Little or no nutritional ... -DPG -> - hemolysis ... - anemia ... #diagnosis #pathophysiology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... • Compensated hemolysis ... IgM) • Blood smear ... intravascular hemolysis
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
to be seen in hemolytic ... microangiopathic hemolytic ... anemia in which ... - uremic syndromes ... BloodSmear #Blood #Smear
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