12 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... heliotrope rash, Shaw sign ... , holster sign, ... see mechanics hands ... #diagnosis #rheumatology
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
skin thickening Signs ... and Symptoms: ... acro-osteolysis, myositis ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Hypothyroidism and Hyperthyroidism - Symptoms and Signs
Hypothyroidism:
 - General - From asymptomatic to myxedema coma, “Like
Hyperthyroidism - Symptoms ... and Signs Hypothyroidism ... Dermatopathy Ø Hands ... Amy Chung, MD, MSc ... #Signs #Diagnosis
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
anemia 4% - Myositis ... malignancies, Multiple sclerosis ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Spasticity - Reflexes ... • Bilateral signs ... and/or symptoms ... Oligoclonal IgG bands ... : - Multiple sclerosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
: Pathogenesis and ... clumsiness in hands ... rectal reflex. ... pathophysiology #signs ... #symptoms #msk
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
and signs below ... : - Multiple sclerosis ... - Transverse myelitis ... Scleroderma, Systemic sclerosis ... dysfunction • Abnormal reflexes
Diffuse Systemic Sclerosis (Scleroderma)
 - Pulmonary Fibrosis -> Crackles, Abnormal CXR
 - Pulmonary Hypertension, Right Heart
Diffuse Systemic Sclerosis ... esophageal dilation, reflux ... Renal Failure - Mask ... pathophysiology #signs ... #symptoms #diagnosis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, particularly scleritis ... purpura: Strong sign ... • Progressive symptoms ... occasional oligoclonal bands ... Differential #Diagnosis #Rheumatology