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diagnosis differential causes agglutinin atlas cold deficiency disease ferritin index key macrocytic microcytic morphology normocytic production reticulocyte workup
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Hemolysis - Differential ... Extravascular ... #Intravascular ... #Extravascular # ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
vs Extravascular ... hemoglobinuria (PNH) Extravascular ... #Hemolytic #Intravascular ... #Extravascular ... differential #diagnosis #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Bleed • Hemolysis ... Microangiopathic Hemolytic ... - Sickle Cells, ... • Early Iron ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... , Disseminated intravascular ... #differential #hematology
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... loss: Intravascular ... (not extravascular ... ) hemolysis, Intensive ... #ferritin #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Iron ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... . sickle cell anemia ... Production #Index #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
corpuscular (cell ... Red cell distribution ... acute blood loss, hemolysis ... substrate (e.g. iron ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... causing intravascular ... hemolysis on rewarming ... #anemia #hematology
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