11 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Intravascular ... vs Extravascular ... hemolytic anemia ... #Hemolytic #Intravascular ... differential #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Hemolysis - Differential ... Extravascular ... #Intravascular ... #Extravascular # ... #Causes #Hematology
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... and hemolysis: ... Abnormal peripheral smear ... Immune-mediated Hemolysis ... #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
hemolytic anemia ... hemolytic anemia ... as disseminated intravascular ... #hemolytic #anemia ... #Hematology #Pathology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Bleed • Hemolysis ... Fragments • Microangiopathic ... Hemolytic Anemias ... - Sickle Cells, ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... , Disseminated intravascular ... #differential #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Retroperitoneal, Uterine • Hemolysis ... hemolytic anemia ... defects (e.g. sickle cell ... Production #Index #hematology ... #diagnosis #calculation
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
In the right photo ... to be seen in hemolytic ... hemolytic anemia ... include disseminated intravascular ... coagulation, hemolytic
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... causing intravascular ... hemolysis on rewarming ... #anemia #hematology
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
complete blood count (CBC ... as a peripheral smear ... for evidence of microangiopathic ... hemolytic anemia ... #Disseminated #Intravascular