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diagnosis differential hyperkalemia pharmacology causes cardiology hypokalemia nephrology antiarrhythmics classes management medications treatment acidosis antiarrhythmic av avnrt criticalcare digoxin disorders
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Vaughan Williams Classification ... duration CLASS 2 - Beta ... repolarization CLASS 3 - Potassium ... alpha & beta adrenergic ... #Classes #pathophysiology
Antiarrhythmic Medications - Vaughan Williams Classification - Summary Table Class I agents - Sodium Channel Blockers⠀ Class II
Vaughan Williams Classification ... this class are beta ... blockers.⠀ Class ... III agents - Potassium ... #Medications #Classification
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Differential Diagnosis Algorithm ... cells: Insulin, Beta-Agonist ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #low #pathophysiology
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... Release: NSAIDs, Beta-Blockers ... #Hyperkalemia #Pathophysiology ... Pharmacology #Impaired #Potassium
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Vaughan Williams Classification ... duration CLASS 2 - Beta ... repolarization CLASS 3 - Potassium ... alpha & beta adrenergic ... #Classes #pathophysiology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
inhibition (NSAIDs, Beta-Blockers ... Angiotensin II Receptor Blockers ... Sodium-channel blockers ... differential #diagnosis #pathophysiology ... #pharmacology #potassium
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Differential Diagnosis Algorithm ... Alkalosis • ↑ beta ... vomiting) • Low ... #nephrology #low ... #potassium
The Diagnostic Approach to Hyperkalemia Drugs - Amiloride - Spironolactone - Triamterene - Trimethoprim - Pentamidine -
deficiency - Heparin/ LMW ... Ketoconazole Low ... - NSAlDs - Beta-Blockers ... #Hyperkalemia #Algorithm
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pharmacology and Pathophysiology ... - When digoxin blocks ... Since digoxin blocks ... hypokalemia (or low ... #Pharmacology #Pathophysiology
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Hyperkalemia Treatment Algorithm ... bradycardia, AV blocks ... Combo of insulin + beta-agonist ... glucose <100 • Beta-agonist ... treatment Remove potassium
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