2212 results
Approach to Neonatal Jaundice

Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
(1) increased bilirubin ... , (2) impaired bilirubin ... or (3) impaired bilirubin ... Jaundice #Algorithm #Differential
Jaundice Differential Diagnosis: A short guide

By Dr. Khudhur Mohammed @khudhur_moh

#jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
Jaundice Differential ... gastroenterology #algorithm #differential ... hyperbilirubinemia #bilirubin
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
predominantly indirect bilirubin ... • Increased bilirubin ... ) • Impaired bilirubin ... Faulty excretion of bilirubin ... #unconjugated #differential
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm

1. Definition: T.bili elevation + >20% conjugated
2. Obtain RUQ
Hyperbilirubinemia - Differential ... Hyperbilirubinemia #direct #bilirubin ... #Differential #
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias - Differential ... / unconjugated bilirubin ... Hemolytic #Anemias #Differential
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Increased Serum bilirubin ... Anemia #Algorithm #Differential
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Microangiopathy (TMA) - Differential ... Total/indirect bilirubin ... Microangiopathy #TMA #Differential
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
fold elevation, Bilirubin ... fold elevation, Bilirubin ... but variable ++, Bilirubin ... hepatitis #comparison #differential
Abnormally Colored Urine - Differential Diagnosis Framework
Red:
 - Hematuria, Hemoglobinuria, Myoglobinuria
 - Beets, Rhubarb, Blackberries, Artificial
Colored Urine - Differential ... Dehydration, Increased bilirubin ... Discoloration #Differential
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
haptoglobin ↑ indirect bilirubin ... • Blood smear: Differential