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diagnosis symptoms pathophysiology differential nephrology pharmacology algorithm hypophosphatemia table workup comparison endocrinology binders causes clinical framework hepatology hyperphosphatemia management pagetsdisease
Pharmacology of diuretics Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Half-Life, Onset, Bioavailability ... , Absorption #
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
heparin Acute Phosphate ... Exogenous: Excessive phosphate ... intake, Phosphate ... Increased Renal Phosphate ... Absorption:
Hypophosphatemia - Differential Diagnosis Algorithm • Decreased intake/absorption: Starvation, Alcoholism, Malabsorption, Phosphate binder use • Redistribution/
Decreased intake/absorption ... Malabsorption, Phosphate ... causes #nephrology #phosphate
Hyperphosphatemia - Differential Diagnosis Algorithm Transcellular Shift: • Rhabdomyolysis • Tumor Lysis • Metabolic or Respiratory Acidosis
Increased Intake / Absorption ... Hypervitaminosis D • Phosphate ... Supplementation • Phosphate
Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Appropriately Low Kidney Phosphate ... • Decreased GI Absorption ... Diarrhea, Antacids, Phosphate ... Inappropriately High Kidney Phosphate
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
, ↑Vitamin D, ↓Phosphate ... ↓Vitamin D, ↑↓Phosphate ... , ↓Vitamin D, ↑Phosphate ... Symptoms: Commonly no signs
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Fractional Excretion of Phosphate ... diarrhea, Poor absorption ... Framework #Workup #phosphate
Characteristics of Commonly Used Phosphate Binders Aluminum - Potent and effective - Useful for
Commonly Used Phosphate ... - No systemic absorption ... - Significant absorption ... significant systemic absorption ... amzn.to/34t5DgJ #Phosphate
The following table from MacGregor (1997) summarizes the bioavailability of many commonly used antibiotics: #EBM #Pharmacology #InfectiousDiseases
summarizes the bioavailability ... #Antibiotics #Absorption ... PeakSerumLevels #Bioavailability
Total-Body Deficits in Chronic Alcohol-Use Disorder. Patients with chronic alcohol-use disorder may have total-body deficits of
total-body deficits of phosphate ... gastrointestinal absorption
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