31 results
Causes of False Elevation and Reduction in HbA1c

== False Elevation ==
Decreased RBC turnover 
• Iron, B-12,
Causes of False ... Iron, B-12, or folate ... deficiency • ... Content • RBC Transfusions ... blood loss • Hemolytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... HUS) • Other: Transfusion ... implicated) - Transfusion ... G6PD deficiency) ... Extravascular #Causes
Folate Deficiency - Causes of Decreased Folic Acid
↓ Intake: Diet, Age, Alcohol
↑ Demand: Pregnancy, Infancy, Hemolysis,
Folate Deficiency ... - Causes of Decreased ... Pregnancy, Infancy, Hemolysis ... @drkeithsiau #Folate ... #Deficiency #FolicAcid
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Etiologies of Folate Deficiency
 • Decreased dietary intake - uncommon in this era
 • Increased requirements
Deficiency • Decreased ... pregnant have hemolytic ... that can cause ... deficiency are ... anticonvulsants lead to increase
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Immune mediated hemolysis ... disease, drugs, transfusions ... Diagnosis #Algorithm #causes
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Febrile Non-Hemolytic ... recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Diagnosis Algorithm Decreased ... WBCs - Decreased ... Bleed • Hemolysis ... • Early Iron Deficiency
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
venipuncture • Hemolysis ... - Transfusion ... paralysis - Insulin deficiency ... Mineralocorticoid deficiency ... differential #diagnosis #causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Algorithm Decreased ... • Folate Deficiency ... • Folate Antagonist ... Diagnosis #Algorithm #Causes