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diagnosis differential hematology folicacid management nutrition abnormal algorithm anemia blood coagulation color dic discoloration disseminated dm2 elevation extravascular false fe
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... HUS) • Other: Transfusion ... G6PD deficiency) ... #Hemolytic #Intravascular ... #Causes #differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Iron, B-12, or folate ... deficiency • ... Content • RBC Transfusions ... blood loss • Hemolytic
Folate Deficiency - Causes of Decreased Folic Acid ↓ Intake: Diet, Age, Alcohol ↑ Demand: Pregnancy, Infancy, Hemolysis,
Folate Deficiency ... - Causes of Decreased ... Pregnancy, Infancy, Hemolysis ... @drkeithsiau #Folate ... #Deficiency #FolicAcid
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... recipients w/ IgA deficiency ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... pregnant have hemolytic ... that can cause ... deficiency are ... anticonvulsants lead to increase
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
Causes of Iron Deficiency ... • Iron loss: Intravascular ... hemolysis, (PNH ... MALABSORPTION • Decreased ... tony_breu #Iron #Deficiency
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... incompatible blood transfusion ... thrombopoietin deficiency ... Treat primary cause ... #Disseminated #Intravascular
Causes Abnormal Urine Color - Differential Diagnosis Turbid White Urine (Albinuria): • Chyluria, Filariasis, Schistosomiasis, Malignancy, Phosphaturia,
Causes Abnormal ... Syndrome - UTI caused ... hemolysis (G6PD ... deficiency, sickle ... , thalassemia, transfusion
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... Tourniquet use - Hemolysis ... Potassium-containing drugs - Transfusion ... aged blood - Hemolysis ... tissue necrosis Decreased
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