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diagnosis differential potassium high nephrology hba1c hematology management product reactions @dharsaty algorithm dm2 eas elevation false fructosamine glycatedproteins hemoglobina1c increase
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... Content • RBC Transfusions ... turnover • Acute blood ... loss • Hemolytic ... #HgbA1c #Laboratory
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Transfusion Thresholds ... Causes purpura & ... TRALI): Leading cause ... Hypocalcemia, Hyperkalemia
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Crush injury • Blood ... transfusion • ... - Transfusion ... Blood transfusion ... differential #diagnosis #causes
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Tissue injury • Hemolysis ... dietary intake • Blood ... transfusion • ... of injection Decreased
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Crush injury • Blood ... transfusion • ... - Transfusion ... Blood transfusion ... differential #diagnosis #causes
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... Causes purpura & ... TRALI): Leading cause ... Hypocalcemia, Hyperkalemia ... more likely to cause
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Hyperkalemia: Diagnostic ... algorithm Decreased ... Potassium-rich diet • Blood ... transfusion • ... Tumor lysis/hemolysis
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... tacrolimus) - Decrease ... Crush injury, Hemolysis ... : Blood draw error ... Differential #Diagnosis #Causes
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... Potassium-containing drugs - Transfusion ... of aged blood ... - Hemolysis (in ... tissue necrosis Decreased
Hemoglobin A1c (glycated hemoglobin) reflects the average blood glucose concentration over the course of the RBC
reflects the average blood ... correlated with 35-76% decrease ... women with normal HgbA1c ... span, such as hemolytic ... transfusions.
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