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diagnosis differential hyperkalemia nephrology glomerular hematology management nephrotic testing @dharsaty blood disease dm2 eas elevation false fructosamine glomerulonephritis glycatedproteins hemoglobina1c
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... and Reduction in HbA1c ... Content • RBC Transfusions ... blood loss • Hemolytic ... Effect • RBC Transfusions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusion Thresholds ... Hemolysis on labs ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Mild-to-moderate decrease ... in most cases; ... Platelet count - Decreased ... nucleated RBCs, and decreased ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Tissue injury • Hemolysis ... intake • Blood transfusion ... of injection Decreased ... Differential #Diagnosis #Causes
Hemoglobin A1c (glycated hemoglobin) reflects the average blood glucose concentration over the course of the RBC
shown by levels of HbA1c ... correlated with 35-76% decrease ... span, such as hemolytic ... frequent blood transfusions ... , #@DharSaty #HbA1c
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
LDH - Assess for hemolysis ... for increased or decreased ... infections are common causes ... glomerular #testing #workup
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
injury, ischemia, hemolysis ... , transfusions), ... reabsorption) Workup ... Pseudohyperkalemia - hemolysis ... only if no clear cause
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... Tourniquet use - Hemolysis ... Potassium-containing drugs - Transfusion ... aged blood - Hemolysis ... tissue necrosis Decreased
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
LDH - Assess for hemolysis ... for increased or decreased ... infections are common causes ... glomerular #disease #workup
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