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diagnosis differential rheumatology bleeding bruising cryoglobulinemia cryoglobulins dermatitis erythema erythematosus gammopathy hypertension lupus lymphomas lymphoproliferative mgrs monoclonal nonhodgkin palm pathophysiology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered ... • Steroids • Vasculitis ... #Causes #Hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... • Low serum C4 complement ... diagnosis #types #classification
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... multifactorial mechanisms Hematologic ... Systemic disorders ... neurofibromatosis, vasculitis ... #Differential #Causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... central nervous system ... against MPO • Complement ... differential #diagnosis #rheumatology ... #classification
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... with lymphatic system ... lymphadenopathy more diffuse ... #Classification ... pathophysiology #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... Skin Disease Classification ... Malignancy (e.g. hematologic ... pneumonitis • Diffuse ... enteropathy, and diffuse
PALM RASHES Common features and patterns: 1. Color: o Red or erythematous: Common in inflammatory or allergic reactions. o Purple or purpuric:
suggest vascular or hematologic ... inflammation (vasculitis ... depigmentation disorders ... causes like eczema ... Drug Reactions: Diffuse
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... or plasma cell disorder ... guide subtype classification ... tubulopathy) - Complement ... formation causing vasculitis
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