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differential vasculitis autoantibodies management patterns symptoms activation conditions cryoglobulinemia cryoglobulins hematology joint laboratory macrophage mas mimickers pain rheumatic rheumatoid sjogrens
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
lupus erythematosus ... lupus erythematosus ... lupus erythematosus ... (SLE), Systemic ... #Antibodies #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... lupus erythematosus ... lupus erythematosus ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Interstitial lung ... , SLE • Pulmonary ... #Extrarticular ... #differential #diagnosis ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... syndrome Arthritis ... #Systemic #Lupus ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... : - Arthritis ... Auto-Antibodies ... and Lupus Mimickers ... #Systemic #Lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... #SLE #systemic ... #erythematosus # ... #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... overlap syndromes ... #lupus #erythematosus ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... salivary ducts Clinical ... MALT Lymphoma • Lung ... #Rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
as systemic lupus ... purpura: strong sign ... LFT • ESR • ANA ... #rheumatology # ... classification
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... rash) • Heart, lung ... lupus erythematosus ... [SLE], AOSD) • ... #Diagnosis #Management
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