18 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
• Lyme disease ... migrans • Lyme disease ... Sarcoidosis • Crohn's disease ... #differential # ... diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... : Lupus (SLE), Systemic ... , Interstitial Pulmonary ... #Antibodies #ANA ... #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
seen in 30—70% of cases ... connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... diseases
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
Lung Disease - ... Differential Diagnosis ... , worse at the bases ... #Lung #Diseases ... #ILD #Causes #Differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... rashErythematous ... Diagnosis: • ANCA-associated ... diseases (i.e. ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... 69% - Malar rash ... Diagnosis and Lupus ... diseases, Hematological ... sclerosis, Still's disease
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
disease, and ocular ... (Granulomatous disease ... rheumatic diseases ... , and SLE) • Urinalysis ... differential #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... involvement: Anti-GBM Disease ... #differential # ... #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
, Whipple's disease ... • Interstitial lung ... , SLEPulmonary ... Vasculitis (e.g. ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... rheumatic diseases ... most important diseases ... disease, and ocular ... #Differential #Diagnosis