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differential management systemic vasculitis classification antibody antineutrophil aortitis arthritis autoantibodies cryoglobulinemia cryoglobulins laboratory polychondritis relapsing rheumatic summary table testing types
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Rheumatic Diseases ... SLE), Sjogren's ... • Rheumatic Diseases ... #patterns #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... tissue disease ... SLE), Sjogren's ... #Antibodies #ANA ... #patterns #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... • Sjögren syndrome ... connective tissue disease ... #antibodies #diagnosis ... diseases
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... (ANA) - 95% - Initial ... #SLE #Summary #diagnosis ... #rheumatology #
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... ), ANCA associated ... Diseases: IgG4- ... Related Disease ... erythematosus (
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Decade Skin Disease ... diseases (i.e. ... ) • Kikuchi disease ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
disease, and ocular ... • Kawasaki Disease ... diseases, such ... LFT • ESR • ANA ... ) pattern: antibodies
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... erythematosus ( ... SLE), rheumatoid
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... multisystemic disease ... Syndrome Diagnosis ... demyelinating disease ... #Syndrome #Rheumatology
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