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diagnosis hematology differential management clinical nephrology rheumatology gammopathy classification oncology algorithm mgus vasculitis cryoglobulinemia pharmacology renal workup anemia causes chronic
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... Ig deposits, C3 ... glomerulopathy w/ monoclonal ... deposits: TMA w/ monoclonal ... ASanchez_PS #Monoclonal
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
rheumatoid arthritis, monoclonal ... complement pathway • C3
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Idiopathic monoclonal ... malignancy (CLL) - Monoclonal ... hemolysis • C3 ... Differential Diagnosis Monoclonal ... Such As: • IgM monoclonal
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Can Feature A Monoclonal ... Amyloidosis and monoclonal ... cryocrystalglobulin GN -C3 ... Paraproteinemias #Hematology #Monoclonal
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
chains - Screen for monoclonal ... for detection of monoclonal ... C3, C4 - Test for
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Monoclonal Gammopathy ... by nephrotoxic monoclonal ... activation (e.g., C3 ... • No Deposits: C3 ... #MGRS #Monoclonal
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
microangiopathy. 5) C3 ... chains - Screen for monoclonal ... for detection of monoclonal
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Complement Levels - C3 ... , C4 • SLE C3 ... • MCGN type 1 C3 ... C4 ↓↓ • Cryo C3 ... C4 ↓↓ • C3GN C3
Nomenclature of Monoclonal Antibodies (-mab) - Dr. Axel Grothey @agrothey #Nomenclature #Monoclonal #Antibodies #Mab #Antibody #Naming
Nomenclature of Monoclonal ... #Nomenclature #Monoclonal
MGRS - Monoclonal Gammopathy of Renal Significance #MGRS #Monoclonal #Gammopathy #Renal #Significance #Diagnosis #Pathology
MGRS - Monoclonal ... Significance #MGRS #Monoclonal
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