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diagnosis differential management signs rheumatology neurology complications lupus sle acute acutelimbischemia agammaglobulinemia algorithm ali amputation ascorbicacid barre bowel classification cli
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Manifestations • Immune Complex ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms
Mechanical Bowel Obstruction and Ileus - Pathogenesis and Clinical Findings Ileus: Functional bowel "blockage", no peristalsis Mechanical Obstruction:
of bowel lumen Complete ... pain and related symptoms ... bowel-movements (suggests complete ... light-switch pain") with complete ... obstruction #sbo #ileus #pathophysiology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
adhesion of IgA complexes ... Formation of immune complexes ... periumbilical region), nausea ... HenochScholeinPurpura #Pathophysiology ... Diagnosis #Signs #Symptoms
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
vascular event -> Complete ... > Often mimics complete ... Brown-Sequard Syndrome -> Complete ... #signs #symptoms ... #msk #orthopedics
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... immunofluorescence Immune Complex ... Glomerulonephritis #Vasculitis
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is
antigen-antibody complexes ... Viral replication causes ... PolyarteritisNodosa #Pathophysiology ... Diagnosis #Signs #Symptoms ... #Vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... tracts Immune Complex ... Vasculitis • ... tract, and often causes ... Presentation - Systemic Symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... inflammation (complex ... Livedo Reticularis, Vasculitis ... Manifestations #pathophysiology ... diagnosis #signs #symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary Epidemiology: - Typically from TB endemic areas -
extrapulmonary cases ... Clinical Signs/Symptoms ... back pain - Symptoms ... decreased reflexes Pathophysiology ... Mycobacterium tuberculosis complex
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
precipitation of a complex ... precipitating complex ... cold insoluble complex ... Cryofibrinogenemia Symptoms ... malignancies, vasculitis
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