8 results
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... antibiody -> Immune Complex ... > Incr Immune Complex ... Vasculitis #HUV #Pathophysiology ... #Rheumatology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
TF complexes with ... FXa which itself complexes ... multicomponent complexes ... multicomponent complexes ... diagnosis #models #hematology
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
Suggested algorithm ... CBC, complete blood ... MGUS #Followup #algorithm ... diagnosis #management #hematology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... immunofluorescence Immune Complex ... differential #diagnosis #algorithm ... #rheumatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Differential Diagnosis Algorithm ... Drug-induced immune-complex ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
Antidotes: • Apixaban ... fragment Prothrombin complex ... anticoagulant #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
♀, ↑Age, ESRD Pathophysiology ... binds heparin-PF4 complex ... Management #Treatment #Hematology
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
multicomponent complexes ... diagnosis #models #hematology ... #pathophysiology