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diagnosis differential anemia management workup aptt coagulation elevatedmcv hepatology macrocytic macrocytosis microcytic prolonged treatment antiepileptics arteritis bilirubinemia bleeding bradycardia bruising
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... (e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... amyloidosis #Abnormal
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Clotting tests can be abnormal ... factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... pathophysiology #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... to one factor e.g ... e.g. heparin ... inhibitory drugs e.g
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... • Secondary (e.g ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Differential Diagnosis Algorithm ... Iron Deficiency (Eg ... Other • e.g ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... • Rule out B12 and ... Deficiency - Abnormal ... #Causes #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Destruction • Abnormal ... Rare • Drugs (e.g ... #Causes #Hematology
Chest Pain - Diagnosis and Workup Algorithm History and Exam Acute life-threatening causes: • Acute myocardial infarction •
Workup Algorithm ... life-threatening causes ... Initial workup: • EKG ... , LET, lipase, PT ... Pain #Diagnosis #Algorithm
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Differential Diagnosis Algorithm ... Chronic Disease Normal ... Chronic Disease (e.g ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
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