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diagnosis management differential abnormal algorithm anemia aptt coagulation lupus neurology prolonged pt sle syndrome treatment workup arteritis autoimmune blood cerebritis
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
How do you work up an ischemic CVA? A) Initial Evaluation • ABCs • IV access, monitor
r/o hemorrhage and ... Cardioembolic: • ECG ... +/- TEE (high Afib ... v Holter (r/o Afib ... workup #diagnosis #checklist
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... (e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... Differential Diagnosis and ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Causes of Localized ... • Infection (e.g ... Infection (Forearm/Hand ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL and ... suspected) • In case ... • Special cases ... (e.g. renal failure ... Measurement #SLE #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Nonspecific inhibitors e.g ... to one factor e.g ... e.g. heparin ... inhibitory drugs e.g ... #differential #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... ischemia and/or ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... • Rule out B12 and ... Diagnosis #Algorithm #Causes ... #Hematology
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