43 results
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
and the aPTT are ... (e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
PT and/or aPTT ... to one factor e.g ... e.g. heparin ... inhibitory drugs e.g ... #differential #hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... Study #diagnosis #hematology ... pathophysiology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Hemophilia - Diagnosis and ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
younger patients and ... • Provoked (e.g ... screening, CBC, aPTT ... Hypercoagulable #Workup #hematology ... diagnosis #algorithm #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... cancer cells (and ... Diagnosis #Management #treatment ... #hematology #differential
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and ... - Vasculitis, e.g ... - Vasculitis, e.g ... diseases #diagnosis #table ... #rheumatology #
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm
Cervical:
 - Anterior
     • Infection
Causes of Localized ... • Infection (e.g ... Infection (Forearm/Hand ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology