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diagnosis syndrome rheumatology differential neurology treatment algorithm aih alcoholic blood causes cirrhosis erythematosus liver lupus nephrology sle systemic table acquired
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Alcohol, Viral hepatitis ... disorders (e.g. ... comparison #diagnosis #hematology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
AST/ALT >1.5, and ... (e.g., severe upper ... use assessment (e.g ... laboratory tests (e.g ... #Hepatology #AIH
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... inflammation (eg ... been reported (eg ... (eg Viral) Management ... #Hepatology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Management • ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... thrombocythemia), Autoimmune ... #treatment #hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... common in SLE, autoimmune ... hepatitis Anti-CCP ... - Vasculitis, e.g ... - Vasculitis, e.g
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
of information (e.g ... vascular disorder (e.g ... steatosis • Autoimmune ... hepatitis #DILI ... Diagnosis #Algorithm #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
of associated autoimmune ... disease (e.g. dryness ... of the eyes and ... specific ANAs (e.g ... Diagnosis #Algorithm #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
AST/ALT >1.5, and ... (e.g., severe upper ... use assessment (e.g ... laboratory tests (e.g ... #AH #hepatology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
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