9 results
diagnosis differential rheumatology autoimmune erythematosus lupus management neurology pathophysiology sle systemic complications cord creatine elevated hematology kinase lymphomas lymphoproliferative musculoskeletal
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Critical Illness Myopathy ... ): • PROXIMAL MUSCLE ... Neuromuscular disorders ... connective tissue disorder ... Inclusion body myositis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Necrotizing myopathy ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... and anti-HMGCR myopathy
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Myositis ... Weakness, Incr CK ... femoral heads • Myopathy ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... symptoms: weeks ... • Myalgia • Myositis ... inclusion body myositis ... Diagnosis: • CK
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... Very high serum CK
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... findings: • Symptoms ... - Transverse myelitis ... cord #spinalcord #disorders ... differential #algorithm
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Focal inflammatory disorder ... the spinal cord (Myelopathy ... Bilateral signs and/or symptoms ... , MOG antibody disorders ... (MOG) antibody disorders
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... Differential Diagnosis Algorithm ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... #Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... erythematosus (SCLE ... ) • Endocrine disorders ... • Transverse Myelitis ... Induced Lupus: • Symptoms
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