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diagnosis differential rheumatology erythematosus lupus management neurology pathophysiology systemic arthropathies arthropathy autoimmune causes complications cord creatine dysphagia elevated esophageal fractures
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Erythematosus (SLE ... - Myositis ... Erythematosus #SLE ... #MSK #Musculoskeletal ... pathophysiology #signs #symptoms
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
): • PROXIMAL MUSCLE ... Neuromuscular disorders ... connective tissue disorder ... , SLE • PROXIMAL ... Inclusion body myositis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... Can also see mechanics
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
Differential Diagnosis Algorithm ... Erythematosus (SLE ... should have other symptoms ... #msk #Differential ... #Diagnosis #Algorithm
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... • Myalgia • Myositis ... erythematosus (SLE ... inclusion body myositis ... Diagnosis: • CK
Dysphagia - Differential Diagnosis Algorithm Oropharyngeal Dysphagia Esophageal Dysphagia • Upper 2/3 (striated muscle): stroke, NMJ
Differential Diagnosis Algorithm ... 2/3 (striated muscle ... ): stroke, NMJ disorders ... , ALS, MS, muscular ... muscular atrophy, SLE
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... - Transverse myelitis ... Behcet disease - SLE ... cord #spinalcord #disorders ... differential #algorithm
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Focal inflammatory disorder ... Bilateral signs and/or symptoms ... Evaluate for NMO, SLE ... , MOG antibody disorders ... : - SLE - Neurosarcoidosis
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm Tumours - See Bone Lesions Scheme Paget's Disease -
Differential Diagnosis Algorithm ... Tumours - See ... Pain/Proximal Muscle ... • Bone Marrow Disorder ... Fractures #Pathologic #MSK
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... Differential Diagnosis Algorithm ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... #Classification
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