23 results
diagnosis differential neurology management rheumatology treatment cord erythematosus lupus myopathy rhabdomyolysis signs sle spinal spinalcord syndromes systemic vasculitis adrenal algorithm
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... less systemic symptoms ... anti-synthetase syndrome
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
- Myositis ... Weakness, Incr CK ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Subacute to Chronic Causes ... ): • PROXIMAL MUSCLE ... myopathy - Autoimmune ... Inclusion body myositis
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... Guillain-Barré syndrome ... inclusion body myositis ... antisynthetase syndrome ... Diagnosis: • CK
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... statins - probably caused
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... Other brainstem syndromes ... positive NMO only): Myositis ... , Comorbid autoimmune ... diagnosis #neurology #symptoms
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Demyelinating Disease (MS ... Tetanus, Transverse Myelitis ... Guillain-Barre syndrome ... aminoglycosides) • Muscles
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Management Summary Causes ... Hyperthyroidism - Autoimmune ... : • Triad of symptoms ... urine • Other symptoms ... Diagnosis #Management #causes
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Bone/Joint Causes ... Lyme disease Muscle ... Causes of Leg Pain ... • Myositis/pyomyositis ... lower #extremity #msk
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
findings: • Symptoms ... Hyperreflexia - Muscle ... Non-compressive Spinal Cord Causes ... - Transverse myelitis ... MCTD, Sjogren syndrome
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