16 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... - Myositis ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... associated with higher CK ... greater level of muscle ... weakness, less systemic ... symptoms, and less
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Myalgia • Myositis ... syndrome (GBS), systemic ... inclusion body myositis ... sclerosis. ... Diagnosis: • CK
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
central nervous system ... neuritis • Partial myelitis ... defect SIGNS/SYMPTOMS ... Signs and symptoms ... /or cerebellar symptoms
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
findings: • Symptoms ... : - Multiple sclerosis ... - Transverse myelitis ... , Scleroderma, Systemic ... sclerosis - MCTD
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Classic - Nodular Sclerosis ... pattern of spread, B symptoms ... Amy Chung, MD, MSc ... Lymphoproliferative #Disorders #Classification ... #pathophysiology
Hydroxyapatite Deposition Disease (HADD) - MSK Radiology
Imaging Findings:
 • Ovoid hypointense structures along the bursal surface
Disease (HADD) - MSK ... within the deltoid muscle ... consistent with myositis ... sclerosis, hyperparathyroidism ... Radiology #diagnosis #msk
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Amyotrophic Lateral Sclerosis ... finding of lateral sclerosis ... Pathophysiology ... of the nervous system ... fasciculations Common Symptoms
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... • Conduction system
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... monophasic Pathophysiology ... Bilateral signs and/or symptoms ... suggestive of multiple sclerosis ... : - Multiple sclerosis