36 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... present in skeletal muscle ... of underlying muscle ... damage. ... useful marker of muscle
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings

Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
tensile strength of muscle ... • Structural damage ... to nerves, muscles ... Diagnosis #signs #symptoms ... #msk #orthopedics
Diabetic Myonecrosis (Diabetic Muscle Infarction)
 • Spontaneous ischemic necrosis of skeletal muscle (anterior thigh or calf)
Myonecrosis (Diabetic Muscle ... necrosis of skeletal muscle ... Microvascular endothelial damage ... with sudden onset muscle ... Common pattern: ↑CK
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Symptoms (SAMS) ... symptoms: weeks ... Diagnosis: • CK ... symptoms (SAMS) ... biopsy if symptoms
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
Radiculopathy: Signs and Symptoms ... can happen) • Muscle ... reflexes (at those muscles ... Radiculopathy #MSK ... diagnosis #signs #symptoms
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Accumulated micro-damage ... StressFractures #msk ... pathophysiology #symptoms
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
associated with higher CK ... greater level of muscle ... less systemic symptoms
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
which impairs musde ... slow-twitching Type I muscle ... Asymptomatic CK ... proximal myopathy → Muscle ... pathophysiology #signs #symptoms
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
- Elevation of muscle ... Creatinine kinase (CK ... Biopsy Findings: Muscle ... - Bilateral Muscle ... Pathophysiology #Signs #Symptoms