290 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs ... #symptoms #diagnosis
Myelopathy - Injury to the entire spinal cord - Signs and Symptoms
 • Ataxia (early sign)
and Symptoms ... Hypertonicity (muscles ... #Myelopathy #diagnosis ... #signs #symptoms ... #msk
Radiculopathy: Signs and Symptoms
 • Back/Neck Pain
 • Decr Range of motion
 • Abnormal posturing
 •
and Symptoms ... can happen) • Muscle ... reflexes (at those muscles ... Radiculopathy #MSK ... #diagnosis #signs
Cubital Tunnel Syndrome: Pathogenesis and clinical findings

 • Paresthesia of 5th and medial half of 4th
test • + Tinel sign ... • Hypothenar muscle ... • + Froment's sign ... CubitalTunnel #Syndrome #Diagnosis ... #symptoms #msk
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm
With Sensory Changes:
Causes of Peripheral ... Algorithm With ... Myopathy - Proximal muscle ... involvement, elevated CK ... #Algorithm #Causes
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase - Causes ... of Elevated CK ... Subacute to Chronic Causes ... ): • PROXIMAL MUSCLE ... #differential #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
associated with higher CK ... greater level of muscle ... less systemic symptoms ... heliotrope rash, Shaw sign ... , holster sign,
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Causes of Peripheral ... - Differential Diagnosis ... Myopathy - Proximal muscle ... involvement, elevated CK ... #Algorithm #Causes
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Injury - AKI Workup Algorithm ... and Differential Diagnosis ... osmolarity If cause ... clinical context and signs ... Rhabdo-myolysis: CK
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
which impairs musde ... Asymptomatic CK ... proximal myopathy → Muscle ... pathophysiology #signs ... #symptoms #endocrinology