13 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... 80%) - Proximal Weakness ... 10%) - Proximal Weakness ... Erythematosus #SLE #MSK ... pathophysiology #signs #symptoms
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm
With Sensory Changes:
Differential Diagnosis Algorithm ... Myopathy - Proximal muscle ... involvement, elevated CK ... #Sensory #Neurology ... Differential #Diagnosis #Algorithm
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Differential Diagnosis Algorithm ... Myopathy - Proximal muscle ... involvement, elevated CK ... #Neurology #Differential ... #Diagnosis #Algorithm
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
associated with higher CK ... greater level of muscle ... weakness, less ... systemic symptoms ... have significant weakness
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Amyotrophic Lateral ... examination finding of amyotrophy ... of the nervous system ... fasciculations Common Symptoms ... Lateral #Sclerosis #neurology
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
proximal myalgia and weakness ... weakness • Soreness ... syndrome (GBS), systemic ... syndrome (LEMS), systemic ... Diagnosis: • CK
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
findings: • Symptoms ... /paralysis - Weakness ... , Scleroderma, Systemic ... disorders #diagnosis #neurology ... differential #algorithm
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Tests: • Measure CK ... (symmetric) • CK ... weakness • CK ... weakness PE: Muscle ... • Conduction system
NINDS Diagnostic Criteria for Guillain Barre Syndrome 
Features Required for Guillain-Barré Syndrome:
 • Progressive muscle weakness
• Progressive muscle ... weakness of more ... , Mild sensory symptoms ... Central nervous system ... diagnosis #criteria #neurology
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
central nervous system ... Spasm, Cramping, Weakness ... objective evidence of neurologic ... vision, Diplopia, Weakness ... diagnosis #management #neurology