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diagnosis differential management rhabdomyolysis clinical algorithm causes rheumatology treatment nephrology comparison myopathy pathophysiology signs symptoms dermatomyositis muscle myopathies myositis neurology
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
Creatine kinase (CK ... Defined based on CK ... • Half-life of CK ... • Myoglobin half-life ... metabolism makes myoglobin
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... Myoglobin levels ... Myoglobin has a ... metabolism makes serum myoglobin ... #myoglobin
Acute Myocardial Infarction - Biomarker time course #Diagnosis #Cardiology #AcuteMyocardialInfarction #AMI #Biomarkers #Enzymes #Troponins #CKMB #Myoglobin
Enzymes #Troponins #CKMB ... #Myoglobin #Trends
Acute Myocardial Infarction - Biomarker time course #Diagnosis #Cardiology #AcuteMyocardialInfarction #AMI #Biomarkers #Enzymes #Troponins #CKMB #Trends #Peaks
Enzymes #Troponins #CKMB
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Rhabdo-myolysis: CK ... , myoglobin • ... syndrome: troponin, CK-MB
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
weakness • Elevated CK ... rash • Elevated CK ... Elevated ESR, Normal CK ... mildly elevated CK ... Myositis: elevated CK
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... ASYMPTOMATIC: Macro CK ... Kinase #Elevated #CK
Usmle step 2 ck Pulmonary diseases (High yield points) #usmle #algorithm
Usmle step 2 ck
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
: Proximal • CK ... : Proximal • CK ... : Proximal • CK ... and distal • CK
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