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management erythematosus lupus differential syndrome systemic criteria oncology treatment activation adies alkaline alp behcet causes cerebritis classification coagulation dic disease
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Erythematosus (SLE ... Disease, PRES Pathophysiology ... #CNS #neurology ... #rheumatology #
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... basal ganglia, CNS ... meningitis), MCC CNS ... collaboration • CNS ... signs #symptoms #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
least 2 joints • Neurologic ... pericarditis • Hematologic ... Classification #Criteria #SLE ... Erythematosus #diagnosis ... #rheumatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... SEROSITIS - RENAL - NEUROLOGIC ... Low complement (C3 ... #Rheumatology # ... SLE #Lupus #Erythematosus
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... cryocrystalglobulin GN -C3 ... Scleromyxedema (CNS ... Paraproteinemias #Hematology ... #Differential #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... and CNS • Headache ... Erythematosus #Diagnosis ... #Rheumatology
Adie's Pupil What? Unknown nature & benign • Regular and mildly dilated pupil (4-6mm); • Light-near dissociaton;
females Differential Diagnosis ... : • CN Ill Palsy ... #Adies #Pupil #PhysicalExam ... #neurology #ophthalmology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... erythematosus [SLE ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Parotid swelling CNS ... nervous system (CNS ... • 8%-27% for CNS ... Sjogrens #Syndrome #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... leukostasis syndrome: CNS ... lymphocytic lymphoma (SLL ... #Leukemia #Hematology ... #Oncology #Diagnosis
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