28 results
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
basal ganglia, CNS ... meningitis), MCC CNS ... collaboration • CNS ... #diagnosis #management ... #signs #symptoms
The diagonal crease in the lobe of the ear (Frank's sign) is a sign theoretically related
the ear (Frank's sign ... coronary artery disease ... groove and coronary disease ... : 17891926 #PhysicalExam ... Earlobe #Clinical #Photo
Terry's Nails

Proximal paleness extending halfway up the nail, often eliminating the lunula. Darker distal band. Seen
advanced age, liver disease ... #Fingernails #PhysicalExam ... #Clinical #Photo ... #Sign
Pemberton's sign- Suggests SVC syndrome, Neck Mass

The Pemberton maneuver is a physical examination tool used to
Pemberton's sign ... - Suggests SVC syndrome ... superior vena cava syndrome ... #PhysicalExam # ... Clinical #Photo
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
mainly AQP4-lgG disease ... mainly MOG-lgG disease ... (AQP4-lgG disease ... pain • Extra-CNS ... neurology #symptoms #signs
Muehrcke's Lines (Leukonychia striata)
Narrow while transverse lines (Not depressed, compared to Beau's lines). Usually 2 or
and nephrotic syndrome ... #Fingernails #PhysicalExam ... #Clinical #Photo ... #Sign
Relapsing Acute Severe Ulcerative Colitis - Management Algorithm
Loss of Response:
 • (Re)consult Colorectal Surgery
 • Assess
Ulcerative Colitis - Management ... Adherence • Assess Disease ... Activity: Flex Sig ... COVID) • TDM: IFX/CNl ... #Colitis #UC #Management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... Cerebrovascular Disease ... Erythematosus #SLE #CNS ... cerebritis #diagnosis #management
Characteristic clinical manifestations of Down syndrome 
 
Typical craniofacial appearance 
 • Round face and flat
manifestations of Down syndrome ... • Hirschsprung disease ... #Downs #Syndrome ... #PhysicalExam # ... Features #Signs
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... highly inflammatory disease ... Periodic fever syndromes ... nervous system (CNS ... #Diagnosis #Management