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rheumatology neurology erythematosus lupus management systemic algorithm ana antibodies antinuclear arthritis autoantibodies autoimmune behcet cord disease headache joint manifestations mimickers
Adie's Pupil What? Unknown nature & benign • Regular and mildly dilated pupil (4-6mm); • Light-near dissociaton;
Adie's Pupil What ... Young females Differential ... Diagnosis: • CN ... #Pupil #PhysicalExam ... #neurology #ophthalmology
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
pain • Extra-CNS ... Comorbid autoimmune disorders ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... • Bilateral signs ... and/or symptoms ... Evaluate for NMO, SLE ... #neurology #differential
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Diagnosis Framework ... Non-neuromuscular disorder ... pulmonary etc) • CNS ... Lack of UMN/LMN signs
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
anemia 4% - Myositis ... Lupusreference #SLE ... autoantibodies #signs ... #symptoms #mimickers ... #differential #
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... - Differential ... and signs below ... - Transverse myelitis ... Behcet disease - SLE
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
symptoms (headache ... Behcet disease) Differential ... Oral aphthae : SLE ... inhibitors • Uveitis- Ophthalmology ... #management #signs
Photophobia and Headache - Differential Diagnosis Framework Why? • The coexistence of photophobia and headache suggests the potential
Diagnosis Framework ... - Autonomic symptoms ... meningeal irritation signs ... Trochlear headache • CNS ... #diagnosis #ophthalmology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... and CNS • Headache ... • Transverse Myelitis ... Induced Lupus: • Symptoms
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... Sjögren Syndrome, Myositis ... Lymphoproliferative Disorders ... #rheumatology #diagnosis ... #differential
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