714 results
CREST Syndrome: Pathogenesis and Clinical Findings

CALCINOSIS (BB-sized, hard nodules in fingers)
RAYNAUD'S Phenomenon
ESOPHAGEAL DYSMOTILITY
SCLERODACTYLY (thickening and tightening
CREST Syndrome: ... distal to MTPs) #CREST
Germ Cell Layers and Derivatives
Ectoderm
 • Neural Crest
 • Neural Tube
 • Surface Ectoderm
Mesoderm
Endoderm

Sarah Lyon @sarahthelyon

#Germ
Ectoderm • Neural Crest
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
Scleroderma) Limited - CREST
Oppenheim's Sign on Physical Exam

There are some alternative maneuvers to search for the classic Babinski sign,
friction over the crest
Calcinosis Cutis in CREST Syndrome

Elderly patient with long standing h/o systemic sclerosis presented with symptoms suggestive
Calcinosis Cutis in CREST ... variant or the CREST ... Calcinosis #Cutis #CREST
Lower GI Bleed - Differential Diagnosis Algorithm

 • Structural: Diverticulosis, Hemorrhoids, Post-polypectomy, Polyps & malignancy, Anal
Congenital/systemic (CREST
Lower GI Bleed - Differential Diagnosis Framework
Structural:
 - Diverticulosis
 - Post-Polypectomy Bleeding
 - Hemorrhoids
 - Polyps
disease: HHT, CREST
Cutaneous Systemic Sclerosis (with CREST)
Visible Raynaud’s phenomenon with sclerodactyly. 
#clinical #photo #dermatology #diagnosis
Sclerosis (with CREST
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anticentromere - CREST
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
weight < 60kg, Creat