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diagnosis differential management rheumatology causes oncology workup chronic classification leukemia pancytopenia thrombocytosis acidosis activation behcets clinical cll colon crohns cutaneous
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... disorders • Celiac disease ... Damage: • Post-op surgery ... effect following treatment ... Iron deficiency anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... bleed, Epistaxis, Surgery ... Gastrectomy, WHDA syndrome ... Structural: Celiac disease ... #ferritin #hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
HLH syndrome 5. ... Bariatric surgery ... Acquired Aplastic Anemia ... Metastatic Disease ... #Hematology
Behcet's Syndrome - Treatment Ulcers: • Treatment: Topical steroids • Prevention: Colchicine • Azathioprine for refractory disease Arthritis:
Behcet's Syndrome ... case by case) • Surgery ... #Syndrome #Treatment ... #management #pharmacology ... #rheumatology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
HLH syndrome 5 ... Bariatric surgery ... Acquired Aplastic Anemia ... Metastatic Disease ... #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Obstructive Pulmonary Disease ... Myasthenia Gravis Pharmacologic ... Chronic Fatigue Syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... with leukopenia, anemia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
involve PNS and CNS ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... leukemia • Lung cancer ... • Cervical cancer
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... cells can indicate disease ... • Neutropenia, anemia ... microglobulin Treatment ... workup #oncology #hematology
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